1009813-26-6
Chemical Structure
Chlorotonil A
- CAS No.: 1009813-26-6
- Formula:C26H32Cl2O4
- Molecular Weight:479.44
IUPAC Name: (4Z,7S,8E,10Z,12E,14E,17S,19Z)-7,16,17-trihydroxydocosa-4,8,10,12,14,19-hexaenoic acid
InChIKey: RQYZFUUTQJMTMJ-JCSZEPHKSA-N
SMILES: O=C1C(Cl)(Cl)C([C@H](C)C(O[C@@H](C)/C=C/C=C\[C@@H](C)[C@@]2([H])[C@]1([H])[C@]3([H])[C@H](C)C=C(C)C[C@@]3([H])C=C2)=O)=O
Biological Activity: Chlorotonil A is an orally active Antibacterial and antimalarial agent. Chlorotonil A is isolated from Sorangium cellulosum. Chlorotonil A inhibits the germination of Clostridioides difficile spores into vegetative cells. Chlorotonil A exhibits antibacterial activity against Gram-positive bacteria and gametocytocidal activity against mature Plasmodium falciparum gametocytes. Chlorotonil A reduces parasitemia in the murine Plasmodium berghei model and prevents recurrent C. difficile infection in mice. Chlorotonil A can be used for research on malaria and Clostridioides difficile infection[1][2][3][4][5].
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Chlorotonil A | Chlorotonil A is an orally active Antibacterial and antimalarial agent. Chlorotonil A is isolated from Sorangium cellulosum. Chlorotonil A inhibits the germination of Clostridioides difficile spores into vegetative cells. Chlorotonil A exhibits antibacterial activity against Gram-positive bacteria and gametocytocidal activity against mature Plasmodium falciparum gametocytes. Chlorotonil A reduces parasitemia in the murine Plasmodium berghei model and prevents recurrent C. difficile infection in mice. Chlorotonil A can be used for research on malaria and Clostridioides difficile infection. | |||||||||||||||||||||
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References
- [1]. Moyo P, et al. Natural Products: A Potential Source of Malaria Transmission Blocking Drugs?. Pharmaceuticals (Basel, Switzerland). 2020 Sep 17;13(9):251.
- [2]. Karcher ML, et al. Construction of a novel reporter strain indicating inhibition of cell wall biosynthesis. Applied microbiology and biotechnology. 2026 Aug 28;110(1):260.
- [3]. Bublitz A, et al. The natural product chlorotonil A preserves colonization resistance and prevents relapsing Clostridioides difficile infection. Cell Host Microbe. 2023 May 10;31(5):734-750.e8. [Content Brief]
- [4]. Hofer W, et al. Regio- and Stereoselective Epoxidation and Acidic Epoxide Opening of Antibacterial and Antiplasmodial Chlorotonils Yield Highly Potent Derivatives. Angewandte Chemie (International ed. in English). 2022 Jul 25;61(30):e202202816.
- [5]. Woldearegai T G. Characterization of Plasmodium falciparum mature gametocytes: lifespan, immunogenicity and susceptibility to novel compounds[D]. Dissertation, Tübingen, Universität Tübingen, 2018, 2018.
