101374-18-9
101374-18-9
Chemical Structure
UCM 793
- CAS No.: 101374-18-9
- Formula:C12H18N2O2
- Molecular Weight:222.29
IUPAC Name: N-(2-((3-methoxyphenyl)(methyl)amino)ethyl)acetamide
InChIKey: FAWOXVGCBAVSFR-UHFFFAOYSA-N
SMILES: O=C(NCCN(C=1C=CC=C(OC)C1)C)C
Biological Activity: UCM 793 is a non-selective MT1/MT2 receptor agonist (pKis: 9.09 (MT1 receptor); 9.19 (MT2 receptor)). UCM793 increases the number of episodes and decreases the length of the episodes of wakefulness. UCM 793 influences quality of the vigilance states. UCM 793 decreases sleep onset without having an effect on NREM sleep maintenance[1][2].
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UCM 793 | UCM 793 is a non-selective MT1/MT2 receptor agonist (pKis: 9.09 (MT1 receptor); 9.19 (MT2 receptor)). UCM793 increases the number of episodes and decreases the length of the episodes of wakefulness. UCM 793 influences quality of the vigilance states. UCM 793 decreases sleep onset without having an effect on NREM sleep maintenance. | |||||||||||||||||||||
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References
- [1]. Ochoa-Sanchez R, et al. Melatonin, selective and non-selective MT1/MT2 receptors agonists: differential effects on the 24-h vigilance states. Neurosci Lett. 2014 Feb 21;561:156-61. [Content Brief]
- [2]. Jockers R, et al. Update on melatonin receptors: IUPHAR Review 20[J]. British journal of pharmacology, 2016, 173(18): 2702-2725.
Keywords
