101439-76-3
Chemical Structure
BML-260
- CAS No.: 101439-76-3
- Formula:C17H11NO3S2
- Molecular Weight:341.40
IUPAC Name: (E)-4-(5-benzylidene-4-oxo-2-thioxothiazolidin-3-yl)benzoic acid
InChIKey: HJGHAHOKZBWVGK-GXDHUFHOSA-N
SMILES: O=C(O)C1=CC=C(N(C/2=O)C(SC2=C\C3=CC=CC=C3)=S)C=C1
Biological Activity: BML-260 is a potent inhibitor of dual-specific phosphatases JSP-1 and DUSP22. BML-260 can activate UCP1 and thermogenesis in adipocytes in a JSP-1-independent manner. The effect of BML-260 on adipocytes is partially achieved through the activation of CREB, STAT3, and PPAR signaling pathways. BML-260 can be used in the research of inflammatory and proliferative disorders associated with JNK signaling dysfunction as well as obesity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BML-260 | 99.65% | BML-260 is a potent inhibitor of dual-specific phosphatases JSP-1 and DUSP22. BML-260 can activate UCP1 and thermogenesis in adipocytes in a JSP-1-independent manner. The effect of BML-260 on adipocytes is partially achieved through the activation of CREB, STAT3, and PPAR signaling pathways. BML-260 can be used in the research of inflammatory and proliferative disorders associated with JNK signaling dysfunction as well as obesity. | ||||||||||||||||||||
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References
- [1]. Williams D R, et al. Targeting phosphatase DUSP22 ameliorates skeletal muscle wasting via Akt independent JNK-FOXO3a repression[J]. bioRxiv, 2024: 2024.04. 08.588643.
- [2]. Feng Z, et al. Identification of a rhodanine derivative BML-260 as a potent stimulator of UCP1 expression[J]. Theranostics, 2019, 9(12): 3501. [Content Brief]
