10149-14-1
Chemical Structure
KDO
Synonym(s): 3-Deoxy-D-manno-2-octulosonic acid
- CAS No.: 10149-14-1
- Formula:C8H14O8
- Molecular Weight:238.19
IUPAC Name: (4R,5R,6R,7R)-4,5,6,7,8-pentahydroxy-2-oxooctanoic acid
InChIKey: KYQCXUMVJGMDNG-SHUUEZRQSA-N
SMILES: OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CC(C(O)=O)=O
Biological Activity: KDO (3-Deoxy-D-manno-2-octulosonic acid) is a characteristic monosaccharide component of capsular polysaccharides of Gram-negative bacteria and meningococcal lipooligosaccharide (LOS), and can also be present in the polysaccharide components of Nelumbo nucifera. KDO together with lipid A constitutes the LOS inner core and is an essential molecule for CD14/TLR4-mediated proinflammatory signaling. KDO can be used in research related to meningococcal disease and inflammation[1][2][3].
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KDO | KDO (3-Deoxy-D-manno-2-octulosonic acid) is a characteristic monosaccharide component of capsular polysaccharides of Gram-negative bacteria and meningococcal lipooligosaccharide (LOS), and can also be present in the polysaccharide components of Nelumbo nucifera. KDO together with lipid A constitutes the LOS inner core and is an essential molecule for CD14/TLR4-mediated proinflammatory signaling. KDO can be used in research related to meningococcal disease and inflammation. | |||||||||||||||||||||
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References
- [1]. Neszmélyi A, Kosma P, Christian R, Schulz G, Unger FM. Empirical 13C-n.m.r.-correlations between the Escherichia coli K 13 and LP 1092 capsular polysaccharides and model oligosaccharides containing D-ribose and 3-deoxy-D-manno-2-octulosonic acid. Carbohydr Res. 1985 Jun 15;139:13-22.
- [2]. Zarantonelli ML, et al. Differential role of lipooligosaccharide of Neisseria meningitidis in virulence and inflammatory response during respiratory infection in mice. Infection and immunity. 2006 Oct;74(10):5506-12.
- [3]. Assignee/Inventors (KR 10-2019-0129245 A). Composition comprising Nelumbo nucifera polysaccharide containing KDO, neutral sugar and uronic acid for immunomodulation. KR 10-2019-0129245 A