1017857-38-3
Chemical Structure
PF-4348235
Synonym(s): β2AR/M-receptor agonist-2
- CAS No.: 1017857-38-3
- Formula:C36H49ClN4O7S
- Molecular Weight:717.31
IUPAC Name: (R)-1-(9-((2-hydroxy-2-(4-hydroxy-3-(methylsulfonamido)phenyl)ethyl)amino)nonyl)piperidin-4-yl (3'-chloro-4'-hydroxy-[1,1'-biphenyl]-2-yl)carbamate
InChIKey: NLEWMFKEAMXROY-DHUJRADRSA-N
SMILES: O[C@H](C1=CC(NS(C)(=O)=O)=C(C=C1)O)CNCCCCCCCCCN(CC2)CCC2OC(NC3=C(C4=CC(Cl)=C(C=C4)O)C=CC=C3)=O
Biological Activity: β2AR/M-receptor agonist-2 (compound 15) is a muscarinic antagonist and β2 adrenoceptor agonist (MABA). β2AR/M-receptor agonist-2 shows potency to β2 adrenoceptor with an EC50 value of 3.7 nM. β2AR/M-receptor agonist-2 also has potency to human cloned M3 receptor with a Ki value of 0.73 nM. β2AR/M-receptor agonist-2 is a potent bronchodilator, it can be used for the research of chronic obstructive pulmonary disease (COPD)[1].
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PF-4348235 | β2AR/M-receptor agonist-2 (compound 15) is a muscarinic antagonist and β2 adrenoceptor agonist (MABA). β2AR/M-receptor agonist-2 shows potency to β2 adrenoceptor with an EC50 value of 3.7 nM. β2AR/M-receptor agonist-2 also has potency to human cloned M3 receptor with a Ki value of 0.73 nM. β2AR/M-receptor agonist-2 is a potent bronchodilator, it can be used for the research of chronic obstructive pulmonary disease (COPD). | |||||||||||||||||||||
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Keywords
