1027330-97-7
1027330-97-7
Chemical Structure
A-943931
- CAS No.: 1027330-97-7
- Formula:C17H21N5
- Molecular Weight:295.38
IUPAC Name: (R)-4-(3-aminopyrrolidin-1-yl)-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidin-2-amine
InChIKey: SDTRYHWIXVHTLM-GFCCVEGCSA-N
SMILES: N[C@@H](C1)CCN1C2=C3CCCC4=CC=CC=C4C3=NC(N)=N2
Biological Activity: A-943931 is a potent and selective histamine H4 receptor (H4R) antagonist with pKi values of 4.6, 3.8 nM for human and rat H4R, respectively. A-943931 shows anti-inflammatory and antinociceptive efficacy[1][2].
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A-943931 | 99.57% | A-943931 is a potent and selective histamine H4 receptor (H4R) antagonist with pKi values of 4.6, 3.8 nM for human and rat H4R, respectively. A-943931 shows anti-inflammatory and antinociceptive efficacy. | ||||||||||||||||||||
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References
- [1]. Ivan Milicic, et al. Identification of two potent and selective histamine H4 receptor antagonists with antipruritic activity. The FASEB journal homepage. 2009.
- [2]. Cowart MD, et al. Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models. J Med Chem. 2008 Oct 23;51(20):6547-57. [Content Brief]
Keywords
