1030610-86-6
Chemical Structure
SGX393
Synonym(s): SGX70393
- CAS No.: 1030610-86-6
- Formula:C21H22N6O
- Molecular Weight:374.45
IUPAC Name: 2-amino-5-(3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl)-N,N-dimethylbenzamide
InChIKey: INAGORZAOFUKOZ-UHFFFAOYSA-N
SMILES: O=C(C=1C=C(C=CC1N)C2=CN=C3NC=C(C3=C2)C4=CC=NN4CC)N(C)C
Biological Activity: SGX393 (SGX70393) is a Bcr-Abl kinase inhibitor. SGX393 binds to the active conformation of the kinase domains of both wild-type and T315I mutant Bcr-Abl, thereby inhibiting kinase activity. SGX393 exhibits antiproliferative effects in cells expressing wild-type or T315I mutant Bcr-Abl, and suppresses T315I-driven tumor growth. SGX393 can be used for the research of chronic myeloid leukemia[1].
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SGX393 | SGX393 (SGX70393) is a Bcr-Abl kinase inhibitor. SGX393 binds to the active conformation of the kinase domains of both wild-type and T315I mutant Bcr-Abl, thereby inhibiting kinase activity. SGX393 exhibits antiproliferative effects in cells expressing wild-type or T315I mutant Bcr-Abl, and suppresses T315I-driven tumor growth. SGX393 can be used for the research of chronic myeloid leukemia. | |||||||||||||||||||||
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