SGX393
SGX393 (SGX70393) is a Bcr-Abl kinase inhibitor. SGX393 binds to the active conformation of the kinase domains of both wild-type and T315I mutant Bcr-Abl, thereby inhibiting kinase activity. SGX393 exhibits antiproliferative effects in cells expressing wild-type or T315I mutant Bcr-Abl, and suppresses T315I-driven tumor growth. SGX393 can be used for the research of chronic myeloid leukemia.
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- CAS. Nr.: 1030610-86-6
- Formel: C21H22N6O
- Molecular Weight:374.45
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
SGX393 potently inhibits the proliferation of Ba/F3 cells expressing WT Bcr-Abl (IC50 = 12 nM) and Bcr-AblT315I (IC50 = 7.3 nM), while being inactive against parental Ba/F3 cells[1].
SGX393 inhibits Bcr-Abl kinase activity in primary CML cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1030610-86-6
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Molecular Weight 374.45
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Formel C21H22N6O
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SMILES
O=C(C=1C=C(C=CC1N)C2=CN=C3NC=C(C3=C2)C4=CC=NN4CC)N(C)C
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Synonyms
SGX70393
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
SGX393 Related Classifications
HY-165532 Related Classifications
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