1031063-36-1
Chemical Structure
(E/Z)-DMU2105
- CAS No.: 1031063-36-1
- Formula:C18H13NO
- Molecular Weight:259.30
IUPAC Name: (E)-3-(naphthalen-2-yl)-1-(pyridin-3-yl)prop-2-en-1-one
InChIKey: VWBDGXJRQZDLRV-CSKARUKUSA-N
SMILES: O=C(C1=CC=CN=C1)/C=C/C2=CC=C3C=CC=CC3=C2
Biological Activity: (E/Z)-DMU2105 (Compound 7k) is a potent and highly selective CYP1B1 inhibitor. (E/Z)-DMU2105 inhibits human CYP1B1 enzyme bound to yeast-derived microsomes with an IC50 value of 10 nM. (E/Z)-DMU2105 also potently inhibits CYP1B1 expressed within ‘live’ recombinant yeast and human HEK293 kidney cells with an IC50 value of 63.65 nM. (E/Z)-DMU2105 can be used for the research of cancer, glaucoma, ischemia and obesity[1].
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(E/Z)-DMU2105 | (E/Z)-DMU2105 (Compound 7k) is a potent and highly selective CYP1B1 inhibitor. (E/Z)-DMU2105 inhibits human CYP1B1 enzyme bound to yeast-derived microsomes with an IC50 value of 10 nM. (E/Z)-DMU2105 also potently inhibits CYP1B1 expressed within ‘live’ recombinant yeast and human HEK293 kidney cells with an IC50 value of 63.65 nM. (E/Z)-DMU2105 can be used for the research of cancer, glaucoma, ischemia and obesity. | |||||||||||||||||||||
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Keywords
