1035572-38-3
1035572-38-3
Chemical Structure
LEO 29102
- CAS No.: 1035572-38-3
- Formula:C20H22Cl2N2O5
- Molecular Weight:441.31
IUPAC Name: 2-(6-(2-(3,5-dichloropyridin-4-yl)acetyl)-2,3-dimethoxyphenoxy)-N-propylacetamide
InChIKey: HOKIHKLKOZWCRY-UHFFFAOYSA-N
SMILES: COC1=C(C=CC(C(CC2=C(C=NC=C2Cl)Cl)=O)=C1OCC(NCCC)=O)OC
Biological Activity: LEO 29102 is a potent phosphodiesterase 4 (PDE4) inhibitor with an IC50 value of 5 nM. LEO 29102 inhibits TNFα release. LEO 29102 has the potential for the research of atopic dermatitis[1].
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LEO 29102 | LEO 29102 is a potent phosphodiesterase 4 (PDE4) inhibitor with an IC50 value of 5 nM. LEO 29102 inhibits TNFα release. LEO 29102 has the potential for the research of atopic dermatitis. | |||||||||||||||||||||
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References
- [1]. Felding J, et al. Discovery and early clinical development of 2-{6-[2-(3,5-dichloro-4-pyridyl)acetyl]-2,3-dimethoxyphenoxy}-N-propylacetamide (LEO 29102), a soft-drug inhibitor of phosphodiesterase 4 for topical treatment of atopic dermatitis. J Med Chem. 2014 Jul 24;57(14):5893-903. [Content Brief]
