1035875-01-4
Chemical Structure
RETRA hydrobromide
- CAS No.: 1035875-01-4
- Formula:C11H12BrNO3S2
- Molecular Weight:350.25
IUPAC Name: 2-((4,5-dihydrothiazol-2-yl)thio)-1-(3,4-dihydroxyphenyl)ethan-1-one hydrobromide
InChIKey: GUNFIDRZOBRQCN-UHFFFAOYSA-N
SMILES: O=C(CSC1=NCCS1)C2=CC=C(C(O)=C2)O.Br
Biological Activity: RETRA (hydrobromide) is a mutant p53-dependent activator of p73 that can inhibit cancer cells carrying mutant p53. RETRA (hydrobromide) increases the expression level of p73, induces transcriptional activation of several common to transcriptional targets p53 and p73, which leads to mutant p53- and p73-dependent inhibition of tumor growth, reduction of colony formation and induction of effector caspases[1].
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RETRA hydrobromide | RETRA (hydrobromide) is a mutant p53-dependent activator of p73 that can inhibit cancer cells carrying mutant p53. RETRA (hydrobromide) increases the expression level of p73, induces transcriptional activation of several common to transcriptional targets p53 and p73, which leads to mutant p53- and p73-dependent inhibition of tumor growth, reduction of colony formation and induction of effector caspases. | |||||||||||||||||||||
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Keywords
