104073-72-5
Chemical Structure
YM-16638
Synonym(s): YM 638
- CAS No.: 104073-72-5
- Formula:C18H22N2O5S3
- Molecular Weight:442.57
IUPAC Name: 2-((5-((3-(4-acetyl-3-hydroxy-2-propylphenoxy)propyl)thio)-1,3,4-thiadiazol-2-yl)thio)acetic acid
InChIKey: RRUNJEUMTFLLDY-UHFFFAOYSA-N
SMILES: O=C(O)CSC1=NN=C(SCCCOC2=CC=C(C(C)=O)C(O)=C2CCC)S1
Biological Activity:
YM-16638 is an orally active leukotriene (LT) antagonist. YM-16638 can inhibit the production of LTC4, LTD4, and LTE4 in guinea pig trachea, with IC50 values of 0.05 μM, 0.16 μM, and 0.096 μM, respectively. YM-16638 has a dose-dependent inhibitory effect on antigen-induced early and late respiratory responses in allergic sheep[1].
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YM-16638 | YM-16638 is an orally active leukotriene (LT) antagonist. YM-16638 can inhibit the production of LTC4, LTD4, and LTE4 in guinea pig trachea, with IC50 values of 0.05 μM, 0.16 μM, and 0.096 μM, respectively. YM-16638 has a dose-dependent inhibitory effect on antigen-induced early and late respiratory responses in allergic sheep. |
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