10488-36-5
10488-36-5
Chemical Structure
Tofenacin hydrochloride
Synonym(s): TOF hydrochloride
- CAS No.: 10488-36-5
- Formula:C17H22ClNO
- Molecular Weight:291.82
IUPAC Name: N-methyl-2-(phenyl(o-tolyl)methoxy)ethan-1-amine hydrochloride
InChIKey: YAXWIYFUVISXRS-UHFFFAOYSA-N
SMILES: CNCCOC(C1=C(C)C=CC=C1)C2=CC=CC=C2.Cl
Biological Activity: Tofenacin hydrochloride (TOF hydrochloride) is an orally active weak anticholinergic compound. Tofenacin hydrochloride can be used to study extrapyramidal symptoms and depressive side effects associated with the use of Fluphenazine decanoate (HY-B1904) [1][2][3][4].
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Tofenacin hydrochloride | Tofenacin hydrochloride (TOF hydrochloride) is an orally active weak anticholinergic compound. Tofenacin hydrochloride can be used to study extrapyramidal symptoms and depressive side effects associated with the use of Fluphenazine decanoate (HY-B1904) . | |||||||||||||||||||||
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Tofenacin hydrochloride salt-d-d4 | Tofenacin-d4 (hydrochloride) is the deuterium labeled Tofenacin hydrochloride. | |||||||||||||||||||||
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References
- [1]. Altamura AC, e al. Residual neuroleptic-induced parkinsonian symptoms in schizophrenia. A naturalistic study with orphenadrine. Pharmacopsychiatry. 1989 Nov;22(6):246-9.
- [2]. Capstick N, et al. A comparative trial of orphenadrine and tofenacin in the control of depression and extrapyramidal side-effects associated with fluphenazine decanoate therapy. The Journal of international medical research. 1976;4(6):435-40.
- [3]. Hespe W, et al. Aspects of the biliary excretion of orphenadrine and its N‑demethylated derivative, tofenacin, in the rat. Eur J Pharmacol. 1970 Dec;13(1):113‑122.
- [4]. Mason ST, et al. Chronic and acute administration of typical and atypical antidepressants on activity of brain noradrenaline systems in the rat thiopentone anaesthesia model. Psychopharmacology. 1984;84(3):304-9.
