10500-82-0
Chemical Structure
Famotine hydrochloride
Synonym(s): UK 2054 hydrochloride
- CAS No.: 10500-82-0
- Formula:C16H15Cl2NO
- Molecular Weight:308.20
IUPAC Name: 1-((4-chlorophenoxy)methyl)-3,4-dihydroisoquinoline hydrochloride
InChIKey: XWPQCMLTRJWFKB-UHFFFAOYSA-N
SMILES: ClC1=CC=C(OCC2=NCCC3=C2C=CC=C3)C=C1.Cl
Biological Activity: Famotine hydrochloride (UK 2054 hydrochloride) is a broad-spectrum antiviral agent as well as an inhibitor of viral and bacterial neuraminidase. Famotine hydrochloride blocks the uptake of Influenza Virus, delays the viral eclipse phase and release, binds reversibly to influenza virus particles, and competes for host cell receptors. Famotine hydrochloride inhibits viral growth and cytopathic effects in vitro, directly inactivates viruses, and interferes with intracellular viral replication steps. Famotine hydrochloride can be used in studies related to viral infections[1][2][3].
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Famotine hydrochloride | Famotine hydrochloride (UK 2054 hydrochloride) is a broad-spectrum antiviral agent as well as an inhibitor of viral and bacterial neuraminidase. Famotine hydrochloride blocks the uptake of Influenza Virus, delays the viral eclipse phase and release, binds reversibly to influenza virus particles, and competes for host cell receptors. Famotine hydrochloride inhibits viral growth and cytopathic effects in vitro, directly inactivates viruses, and interferes with intracellular viral replication steps. Famotine hydrochloride can be used in studies related to viral infections. | |||||||||||||||||||||
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- [1]. Barry RD. The effects of UK2054 on the multiplication of influenza viruses. J Hyg (Lond). 1970 Mar;68(1):151-8.
- [2]. Togo Y, et al. Antiviral effect of 3, 4-dihydro-1-isoquinolineacetamide hydrochloride in experimental human rhinovirus infection. Antimicrobial agents and chemotherapy. 1973 Dec;4(6):612-6. [Content Brief]
- [3]. Murphy BR. The antiviral activity of 3,4-dihydro-1-isoquinolineacetamide hydrochloride on columbia sk virus infection in mice and tissue culture. Annals of the New York Academy of Sciences. 1970;173(1):255-273.
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