Famotine hydrochloride

Famotine (UK 2054) (14-28 μg/mL; 18 hr) hydrochloride inhibits the proliferation of influenza A virus strains A/PR 8/34 and A2/Singapore/1/57, as well as Newcastle disease virus, in chicken embryo allantoic membrane shell fragments^[1].
Famotine (5-20 μg/mL; 24 hr) hydrochloride at a concentration of 5 μg/mL prolongs the eclipse phase and slows the release of influenza A2/Singapore/1/57 virus in chicken embryo allantoic membrane shell fragments without reducing viral yield; at a concentration of 20 μg/mL, it further delays the above processes and reduces the final viral yield^[1].
Famotine (20 μg/mL; 30 min to 2 hr) hydrochloride inhibits the invasion of influenza virus strain A2/Singapore/1/57 into chorioallantoic membrane tissue blocks on chick embryo shells when administered either before infection or within the first 2 hours post-infection, with the strongest efficacy observed when administered prior to infection^[1].
Famotine (500 μg/mL; 2 hr) hydrochloride interacts reversibly with influenza virus particles of the A2/Singapore/1/57 strain^[1].
Famotine hydrochloride inhibits the proliferation of chicken plague virus in chicken allantoic cells at a concentration of 10 μg/mL, with an inhibition rate of approximately 65%; it only inhibits the proliferation of chicken plague virus in chicken embryo fibroblasts under serum-free conditions, while showing no inhibitory effect under conditions containing 10% calf serum^[1].
Famotine (UK 2054) hydrochloride inhibits the proliferation of rhinovirus type 9 in vitro in HeLa cell cultures, but fails to inhibit the proliferation of this virus in HEL-218 cell cultures^[2].
Famotine (UK 2054) hydrochloride exhibits multi-mechanistic antiviral activity against a variety of viruses, including direct viral inactivation, inhibition of intracellular replication, or exertion of both effects simultaneously depending on the virus type^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.