105565-56-8
105565-56-8
Chemical Structure
BMY 14802
- CAS No.: 105565-56-8
- Formula:C18H22F2N4O
- Molecular Weight:348.39
IUPAC Name: 1-(4-fluorophenyl)-4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)butan-1-ol
InChIKey: ZXUYYZPJUGQHLQ-UHFFFAOYSA-N
SMILES: FC1=CN=C(N2CCN(CCCC(C3=CC=C(C=C3)F)O)CC2)N=C1
Biological Activity: BMY 14802 is a sigma-1 receptor (σ1R) antagonist, as well as an agonist at serotonin (5-HT) 1A and adrenergic alpha-1 receptors. BMY 14802 inhibits abnormal involuntary movement (AIM) in rat Parkinson's disease (PD) model, with down-regulating the expression of AIM[1][2].
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BMY 14802 | 98.07% | BMY 14802 is a sigma-1 receptor (σ1R) antagonist, as well as an agonist at serotonin (5-HT) 1A and adrenergic alpha-1 receptors. BMY 14802 inhibits abnormal involuntary movement (AIM) in rat Parkinson's disease (PD) model, with down-regulating the expression of AIM. | ||||||||||||||||||||
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References
- [1]. Paquette MA, et al. The sigma-1 antagonist BMY-14802 inhibits L-DOPA-induced abnormal involuntary movements by a WAY-100635-sensitive mechanism. Psychopharmacology (Berl). 2009 Jul;204(4):743-54. [Content Brief]
- [2]. Paquette MA, et al. Sigma ligands, but not N-methyl-D-aspartate antagonists, reduce levodopa-induced dyskinesias. Neuroreport. 2008 Jan 8;19(1):111-5. [Content Brief]
Keywords
