1057882-82-2
Chemical Structure
AKR1C3-IN-14
- CAS No.: 1057882-82-2
- Formula:C21H21BrN2O4
- Molecular Weight:445.31
InChIKey: VRVRPZJTYVPJNC-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(Br)C=C1C)CN(C)CC(C2=C(O3)C(C)=C(O)C=C2)=CC3=O
Biological Activity: AKR1C3-IN-14 (compound 4) is an AKR1C3 inhibitor (IC50=0.122 μM) that reduces the overproduction of androgens by inhibiting the activity of the AKR1C3 enzyme, thereby regulating hormone-mediated signaling. AKR1C3-IN-14 also plays a role in the biosynthesis of the prostaglandin PGF2α, regulating cell proliferation by affecting this pathway. AKR1C3-IN-14 can be used in the study of prostate cancer[1].
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AKR1C3-IN-14 | AKR1C3-IN-14 (compound 4) is an AKR1C3 inhibitor (IC50=0.122 μM) that reduces the overproduction of androgens by inhibiting the activity of the AKR1C3 enzyme, thereby regulating hormone-mediated signaling. AKR1C3-IN-14 also plays a role in the biosynthesis of the prostaglandin PGF2α, regulating cell proliferation by affecting this pathway. AKR1C3-IN-14 can be used in the study of prostate cancer. | |||||||||||||||||||||
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Keywords
