1066676-21-8
Chemical Structure
HCAR2 agonist 1
- CAS No.: 1066676-21-8
- Formula:C26H28N4O2
- Molecular Weight:428.53
InChIKey: DJSWNINDPRRCLC-GOSISDBHSA-N
SMILES: CC1=C(C(N[C@H](C)COC2=CC=CC=C2)=O)C=NC3=C(C4=CC=C(C=C4)C(C)C)C=NN13
Biological Activity: HCAR2 agonist 1 (Compound 9n) is a Gi protein-biased allosteric modulator of HCAR2. HCAR2 agonist 1 activates the Gi protein signaling pathway. HCAR2 agonist 1 shows anti-inflammatory effect, and reduces mRNA level of pro-inflammatory cytokine (TNF-α, IL-1β, IL-6, and MCP-1). HCAR2 agonist 1 enhances anti-inflammatory effects of orthosteric agonists in the mouse model of colitis[1].
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HCAR2 agonist 1 | 99.11% | HCAR2 agonist 1 (Compound 9n) is a Gi protein-biased allosteric modulator of HCAR2. HCAR2 agonist 1 activates the Gi protein signaling pathway. HCAR2 agonist 1 shows anti-inflammatory effect, and reduces mRNA level of pro-inflammatory cytokine (TNF-α, IL-1β, IL-6, and MCP-1). HCAR2 agonist 1 enhances anti-inflammatory effects of orthosteric agonists in the mouse model of colitis. | ||||||||||||||||||||
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Keywords
