1067191-08-5
Chemical Structure
ADX68692
- CAS No.: 1067191-08-5
- Formula:C24H23N3O3
- Molecular Weight:401.46
IUPAC Name: N-(4-(2-cyanopropan-2-yl)-3-(pyridin-3-yl)phenyl)-3,4-dimethoxybenzamide
InChIKey: AMOZYIARVZBSIH-UHFFFAOYSA-N
SMILES: CC(C(C(C1=CN=CC=C1)=C2)=CC=C2NC(C3=CC=C(OC)C(OC)=C3)=O)(C#N)C
Biological Activity: ADX68692 is an orally active FSHR negative allosteric regulator, with an IC50 value of 140 nM against hFSHR. ADX68692 antagonizes hCG (HY-107953)-mediated cAMP production, β-arrestin 2 recruitment, and the LH/CGR signaling pathway. ADX68692 partially inhibits testosterone synthesis. ADX68692 blocks follicle growth, disrupts the estrous cycle in rats, and reduces the pregnancy rate in rats. ADX68692 can be used in research related to contraception and endometriosis[1][2][3].
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ADX68692 | ADX68692 is an orally active FSHR negative allosteric regulator, with an IC50 value of 140 nM against hFSHR. ADX68692 antagonizes hCG (HY-107953)-mediated cAMP production, β-arrestin 2 recruitment, and the LH/CGR signaling pathway. ADX68692 partially inhibits testosterone synthesis. ADX68692 blocks follicle growth, disrupts the estrous cycle in rats, and reduces the pregnancy rate in rats. ADX68692 can be used in research related to contraception and endometriosis. | |||||||||||||||||||||
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- [1]. Lazzaretti C, et al. Allosteric modulation of gonadotropin receptors. Frontiers in endocrinology. 2023;14:1179079. [Content Brief]
- [2]. Ayoub MA, et al. Profiling of FSHR negative allosteric modulators on LH/CGR reveals biased antagonism with implications in steroidogenesis. Molecular and cellular endocrinology. 2016 Nov 15;436:10-22. [Content Brief]
- [3]. Dias JA, et al. Inhibition of follicle-stimulating hormone-induced preovulatory follicles in rats treated with a nonsteroidal negative allosteric modulator of follicle-stimulating hormone receptor. Biol Reprod. 2014 Jan 30;90(1):19. . [Content Brief]
Keywords
