1080018-61-6
1080018-61-6
Chemical Structure
NVP-QBE170
- CAS No.: 1080018-61-6
- Formula:C30H36Cl2N16O4
- Molecular Weight:755.62
SMILES: O=C(C1=NC(Cl)=C(N)N=C1N)NC(NC2CCN(CC2)C(C3=CC=C(C(N4CCC(CC4)NC(NC(C5=NC(Cl)=C(N)N=C5N)=O)=N)=O)C=C3)=O)=N
Biological Activity: NVP-QBE170 is a selective Epithelial sodium channel (ENaC) inhibitor with an IC50 of 57.5 nM. NVP-QBE170 potently inhibits ENaC function in HBECs and shows a longer duration of action. NVP-QBE170 significantly attenuates ENaC activity in the airways of guinea pig models. NVP-QBE170 can be used for hyperkalaemia research[1].
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NVP-QBE170 | NVP-QBE170 is a selective Epithelial sodium channel (ENaC) inhibitor with an IC50 of 57.5 nM. NVP-QBE170 potently inhibits ENaC function in HBECs and shows a longer duration of action. NVP-QBE170 significantly attenuates ENaC activity in the airways of guinea pig models. NVP-QBE170 can be used for hyperkalaemia research. | |||||||||||||||||||||
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