1080650-67-4
Chemical Structure
SUN13837
- CAS No.: 1080650-67-4
- Formula:C21H29N5O2
- Molecular Weight:383.49
IUPAC Name: ((2R,5R)-5-(6-(amino-15N)-9H-purin-9-yl-13C5-15N4)-3,4-dihydroxytetrahydrofuran-2-yl-2,3,4,5-13C4)methyl-13C tetrahydrogen triphosphate
InChIKey: UFFJZHVXSNLCEE-UHFFFAOYSA-N
SMILES: CC1=NC(OCC(N(C2CCN(CC2)CC3=CC=CC=C3)C)=O)=NC(C)=C1N
Biological Activity: SUN13837 is an orally active, blood-brain barrier permeable FGFR modulator and neuroprotective agent. SUN13837 mimics the activity of basic fibroblast growth factor, stimulates intracellular tyrosine phosphorylation of FGFR and signal transduction in neuronal cells, induces neurite outgrowth, and inhibits glutamate-induced neuronal death. SUN13837 can be used in research related to acute cervical spinal cord injury and severe spinal cord injury[1][2][3].
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SUN13837 | 99.18% | SUN13837 is an orally active, blood-brain barrier permeable FGFR modulator and neuroprotective agent. SUN13837 mimics the activity of basic fibroblast growth factor, stimulates intracellular tyrosine phosphorylation of FGFR and signal transduction in neuronal cells, induces neurite outgrowth, and inhibits glutamate-induced neuronal death. SUN13837 can be used in research related to acute cervical spinal cord injury and severe spinal cord injury. | ||||||||||||||||||||
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- [1]. Levinson B, et al. SUN13837 in treatment of acute spinal cord injury, the ASCENT-ASCI Study[J]. Clin Neurol Neurosci, 2018, 2(1): 1.
- [2]. Sakai H, et al. Fibroblast growth factor receptor modulators employing diamines with reduced phospholipidosis-inducing potential. Bioorg Med Chem. 2020;28(14):115562. [Content Brief]
- [3]. Imagama S, et al. Systemic treatment with a novel basic fibroblast growth factor mimic small-molecule compound boosts functional recovery after spinal cord injury. PLoS One. 2020;15(7):e0236050. Published 2020 Jul 17. [Content Brief]
Keywords
