108375-77-5
Chemical Structure
PC-766B
Synonym(s): Antibiotic PC-766B
- CAS No.: 108375-77-5
- Formula:C43H68O12
- Molecular Weight:776.99
IUPAC Name: (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-((2S,3R,4S)-4-((2R,4R,5S,6R)-4-(((2R,4R,5S,6R)-4,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-hydroxy-5-methyl-6-((1E,3E)-penta-1,3-dien-1-yl)tetrahydro-2H-pyran-2-yl)-3-hydroxypentan-2-yl)-8-hydroxy-3,15-dimetho
InChIKey: GBRLJEHLCUILHG-OIZCXYEVSA-N
SMILES: O=C1O[C@@H]([C@H](/C=C/C=C(C[C@@H]([C@@H]([C@@H](/C=C(/C=C1\OC)C)C)O)C)\C)OC)[C@H]([C@H]([C@H](C)[C@]2(C[C@H]([C@@H]([C@H](O2)/C=C/C=C/C)C)O[C@H]3C[C@@H](O)[C@H](O)[C@H](O3)C)O)O)C
Biological Activity: PC-766B is a macrolide antibiotic. PC-766B is active against Gram-positive bacteria, and some fungi and yeasts, but inactive against Gram-negative bacteria. PC-766B shows antitumor activity against murine tumor cells. PC-766B has weak inhibitory activity against Na+, K+-ATPase[1][2].
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PC-766B | PC-766B is a macrolide antibiotic. PC-766B is active against Gram-positive bacteria, and some fungi and yeasts, but inactive against Gram-negative bacteria. PC-766B shows antitumor activity against murine tumor cells. PC-766B has weak inhibitory activity against Na+, K+-ATPase. | |||||||||||||||||||||
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References
- [1]. Kumagai K, et, al. PC-766B, a new macrolide antibiotic produced by Nocardia brasiliensis. I. Taxonomy, fermentation and biological activity. J Antibiot (Tokyo). 1993 Jun;46(6):972-8. [Content Brief]
- [2]. Kumagai K, et, al. PC-766B, a new macrolide antibiotic produced by Nocardia brasiliensis. II. Isolation, physico-chemical properties and structure elucidation. J Antibiot (Tokyo). 1993 Jul;46(7):1139-44. [Content Brief]
