108674-87-9
108674-87-9
Chemical Structure
Sergolexole maleate
- CAS No.: 108674-87-9
- Formula:C30H40N2O7
- Molecular Weight:540.65
IUPAC Name: (1r,4R)-4-methoxycyclohexyl (6aR,9R,10aR)-4-isopropyl-7-methyl-4,6,6a,7,8,9,10,10a-octahydroindolo[4,3-fg]quinoline-9-carboxylate maleate
InChIKey: AWRYUNKJBYLYFR-RTFBGVDVSA-N
SMILES: OC(/C=C\C(O)=O)=O.CC(N1C2=C3C([C@]4([H])[C@@](N(C[C@@H](C4)C(O[C@@H]5CC[C@H](CC5)OC)=O)C)([H])CC3=C1)=CC=C2)C
Biological Activity: Sergolexole maleate is a potent 5-HT2 receptor antagonist. Sergolexole maleate antagonizes serotonin-amplified platelet aggregation[1][2].
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Sergolexole maleate | Sergolexole maleate is a potent 5-HT2 receptor antagonist. Sergolexole maleate antagonizes serotonin-amplified platelet aggregation. | |||||||||||||||||||||
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References
- [1]. Cohen ML, et al. 5-Hydroxytryptamine2 receptor antagonist activity of the acid metabolite (1-isopropyl dihydrolysergic acid) of the ergoline ester, sergolexole (LY281067). J Pharmacol Exp Ther. 1989 Dec;251(3):1006-11. [Content Brief]
- [2]. McBride PA, et al. Inhibition of serotonin-amplified human platelet aggregation by ketanserin, ritanserin, and the ergoline 5HT2 receptor antagonists-LY53857, sergolexole, and LY237733. Life Sci. 1990;47(23):2089-95. [Content Brief]
