108868-95-7
Chemical Structure
Andrimid
- CAS No.: 108868-95-7
- Formula:C27H33N3O5
- Molecular Weight:479.57
InChIKey: OHDXGZAYYBMHCY-QSUIEZAASA-N
SMILES: C/C=C/C=C/C=C/C(N[C@H](C1=CC=CC=C1)CC(N[C@@H](C(C)C)C([C@H]2[C@@H](C(NC2=O)=O)C)=O)=O)=O
Biological Activity: Andrimid is a peptide Antibiotic and acetyl-CoA carboxylase inhibitor. Andrimid is produced by symbiotic bacteria of the genus *Enterobacter* residing in the brown planthopper Nilaparvata lugens. Andrimid exhibits strong specific activity against Xanthomonas campestris pv. oryzae. Andrimid shows no or only weak activity against Gram-positive and Gram-negative bacteria, including most plant pathogenic bacteria. Andrimid can be used in studies related to bacterial infections and rice bacterial blight[1][2][3].
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Andrimid | Andrimid is a peptide Antibiotic and acetyl-CoA carboxylase inhibitor. Andrimid is produced by symbiotic bacteria of the genus *Enterobacter* residing in the brown planthopper Nilaparvata lugens. Andrimid exhibits strong specific activity against Xanthomonas campestris pv. oryzae. Andrimid shows no or only weak activity against Gram-positive and Gram-negative bacteria, including most plant pathogenic bacteria. Andrimid can be used in studies related to bacterial infections and rice bacterial blight. | |||||||||||||||||||||
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- [1]. Matilla MA, et al. Biosynthesis of the acetyl-CoA carboxylase-inhibiting antibiotic, andrimid in Serratia is regulated by Hfq and the LysR-type transcriptional regulator, AdmX. Environ Microbiol. 2016;18(11):3635-3650. [Content Brief]
- [2]. Fredenhagen A, et al. Andrimid, a new peptide antibiotic produced by an intracellular bacterial symbiont isolated from a brown planthopper[J]. Journal of the American Chemical Society, 1987, 109(14): 4409-4411.
- [3]. Cheng T, et al. Improved production of andrimid in Erwinia persicina BST187 strain by fermentation optimization. BMC Microbiol. 2023;23(1):268. Published 2023 Sep 25. [Content Brief]
Keywords
