108930-17-2
Chemical Structure
Protein kinase inhibitor H-7 dihydrochloride
- CAS No.: 108930-17-2
- Formula:C14H19Cl2N3O2S
- Molecular Weight:364.29
IUPAC Name: 5-((2-methylpiperazin-1-yl)sulfonyl)isoquinoline dihydrochloride
InChIKey: OARGPFMFRLLKPF-UHFFFAOYSA-N
SMILES: O=S(C1=CC=CC2=C1C=CN=C2)(N3C(C)CNCC3)=O.[H]Cl.[H]Cl
Biological Activity: Protein kinase inhibitor H-7 dihydrochloride is a selective inhibitor of PKC and cyclic nucleotide-dependent protein kinases, with a Ki value of 6.0 μM for rabbit protein kinase C, a Ki value of 3.0 μM for rabbit cAMP-dependent protein kinase, and a Ki value of 5.8 μM for porcine cGMP-dependent protein kinase. Protein kinase inhibitor H-7 dihydrochloride has no effect on Ca2+-calmodulin-dependent enzymes. Protein kinase inhibitor H-7 dihydrochloride regulates the Actin cytoskeleton, inhibits contractility, disrupts stress fibers, induces protrusive activity, stabilizes intercellular junctions, and triggers rapid and reversible cytoskeletal reorganization. Protein kinase inhibitor H-7 dihydrochloride serves as a research tool for elucidating the functions of protein kinase C-mediated signaling systems[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Protein kinase inhibitor H-7 dihydrochloride | 99.63% | Protein kinase inhibitor H-7 dihydrochloride is a selective inhibitor of PKC and cyclic nucleotide-dependent protein kinases, with a Ki value of 6.0 μM for rabbit protein kinase C, a Ki value of 3.0 μM for rabbit cAMP-dependent protein kinase, and a Ki value of 5.8 μM for porcine cGMP-dependent protein kinase. Protein kinase inhibitor H-7 dihydrochloride has no effect on Ca2+-calmodulin-dependent enzymes. Protein kinase inhibitor H-7 dihydrochloride regulates the Actin cytoskeleton, inhibits contractility, disrupts stress fibers, induces protrusive activity, stabilizes intercellular junctions, and triggers rapid and reversible cytoskeletal reorganization. Protein kinase inhibitor H-7 dihydrochloride serves as a research tool for elucidating the functions of protein kinase C-mediated signaling systems. | ||||||||||||||||||||
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Protein kinase inhibitor H-7 dihydrochloride (Standard) | ≥98% | Protein kinase inhibitor H-7 (dihydrochloride) (Standard) is the analytical standard of Protein kinase inhibitor H-7 (dihydrochloride). This product is intended for research and analytical applications. Protein kinase inhibitor H-7 dihydrochloride is a potent PKC (protein kinase C) inhibitor. At 100 μM, Protein kinase inhibitor H-7 dihydrochloride completely inhibits both TPA (skin tumour promoter, 12-O-tetradecanoylphorbol-13-acetate) and phospholipase C-induced ODC (ornithine decarboxylase). | ||||||||||||||||||||
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References
- [1]. Hidaka H, et al. Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C. Biochemistry. 1984 Oct 9;23(21):5036-41. [Content Brief]
- [2]. Kawamoto S, et al. 1-(5-Isoquinolinesulfonyl)-2-methylpiperazine (H-7) is a selective inhibitor of protein kinase C in rabbit platelets. Biochem Biophys Res Commun. 1984;125(1):258-264. [Content Brief]
- [3]. Volberg T, et al. Effect of protein kinase inhibitor H-7 on the contractility, integrity, and membrane anchorage of the microfilament system. Cell Motil Cytoskeleton. 1994;29(4):321-338. [Content Brief]
