1092457-65-2
Chemical Structure
Dolcanatide
- CAS No.: 1092457-65-2
- Formula:C65H104N18O26S4
- Molecular Weight:1681.89
IUPAC Name: (Z)-2-(2-((7-bromobenzo[c][1,2,5]thiadiazol-4-yl)methylene)-3-oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile
InChIKey: NSPHQWLKCGGCQR-HLHYUOOASA-N
SMILES: O=C([C@H](CCC(O)=O)NC([C@H](CC(O)=O)NC([C@H](N)CC(N)=O)=O)=O)N[C@](CSSC[C@@](NC([C@@H](NC([C@@H](NC1=O)C(C)C)=O)C)=O)([H])C(N[C@@](C(NCC(N2)=O)=O)([H])[C@H](O)C)=O)([H])C(N[C@H](C(N[C@@](C(N[C@](CSSC[C@H]2C(N[C@@H](C(O)=O)CC(C)C)=O)([H])C(N[C@H](C(N[C@H]1CC(N)=O)=O)C(C)C)=O)=O)([H])CC(C)C)=O)CCC(O)=O)=O
Biological Activity: Dolcanatide is an orally active GC-C (guanylate cyclase-C) agonist. Dolcanatide shows laxative, anti-nociceptive and anti-inflammatory activity. Dolcanatide can be used in inflammatory bowel disease research[1][2].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
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Dolcanatide | 99.20% | Dolcanatide is an orally active GC-C (guanylate cyclase-C) agonist. Dolcanatide shows laxative, anti-nociceptive and anti-inflammatory activity. Dolcanatide can be used in inflammatory bowel disease research. | ||||||||||||||||||||
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- [1]. Boulete IM, et al. Oral treatment with plecanatide or dolcanatide attenuates visceral hypersensitivity via activation of guanylate cyclase-C in rat models. World J Gastroenterol. 2018 May 7;24(17):1888-1900. [Content Brief]
- [2]. Shailubhai K, et al. Plecanatide and dolcanatide, novel guanylate cyclase-C agonists, ameliorate gastrointestinal inflammation in experimental models of murine colitis. World J Gastrointest Pharmacol Ther. 2015 Nov 6;6(4):213-22. [Content Brief]
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