1092565-44-0
1092565-44-0
Chemical Structure
MMV024101
- CAS No.: 1092565-44-0
- Formula:C16H12N6O2S
- Molecular Weight:352.37
IUPAC Name: 5-(8-(1H-pyrazol-4-yl)-1,5-naphthyridin-2-yl)pyridine-3-sulfonamide
InChIKey: GTWOKQIGBJADIZ-UHFFFAOYSA-N
SMILES: O=S(N)(C1=CC(C2=NC3=C(C=C2)N=CC=C3C4=CNN=C4)=CN=C1)=O
Biological Activity: MMV024101 shows potency against P. falciparum NF54 with an IC50 value of 543 nM, which has antiplasmodial activity[1].
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MMV024101 | MMV024101 shows potency against P. falciparum NF54 with an IC50 value of 543 nM, which has antiplasmodial activity. | |||||||||||||||||||||
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References
- [1]. Kandepedu N, et al. Identification, Characterization, and Optimization of 2,8-Disubstituted-1,5-naphthyridines as Novel Plasmodium falciparum Phosphatidylinositol-4-kinase Inhibitors with in Vivo Efficacy in a Humanized Mouse Model of Malaria. J Med Chem. 2018 Jul 12;61(13):5692-5703. [Content Brief]
Keywords
