1092939-16-6
1092939-16-6
Chemical Structure
Ruxolitinib sulfate
Synonym(s): INCB018424 sulfate
- CAS No.: 1092939-16-6
- Formula:C17H20N6O4S
- Molecular Weight:404.44
IUPAC Name: (R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile sulfate
InChIKey: LGJWVXWQCTZSGC-XFULWGLBSA-N
SMILES: [H][C@@](C1CCCC1)(N2N=CC(C3=C4C=CNC4=NC=N3)=C2)CC#N.O=S(O)(O)=O
Biological Activity: Ruxolitinib sulfate (INCB018424 sulfate) is the first potent, selective JAK1/2 inhibitor to enter the clinic with IC50s of 3.3 nM/2.8 nM, and has > 130-fold selectivity for JAK1/2 versus JAK3.
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Ruxolitinib sulfate | Ruxolitinib sulfate (INCB018424 sulfate) is the first potent, selective JAK1/2 inhibitor to enter the clinic with IC50s of 3.3 nM/2.8 nM, and has > 130-fold selectivity for JAK1/2 versus JAK3. | |||||||||||||||||||||
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Keywords
