109431-87-0
Chemical Structure
(R)-(-)-N-Boc-3-pyrrolidinol
- CAS No.: 109431-87-0
- Formula:C9H17NO3
- Molecular Weight:187.24
IUPAC Name: tert-butyl (R)-3-hydroxypyrrolidine-1-carboxylate
InChIKey: APCBTRDHCDOPNY-SSDOTTSWSA-N
SMILES: O[C@@H]1CCN(C1)C(=O)OC(C)(C)C
Biological Activity: (R)-(-)-N-Boc-3-pyrrolidinol is a chiral pyrrolidine derivative. After undergoing configuration inversion via the Mitsunobu reaction, (R)-(-)-N-Boc-3-pyrrolidinol can serve as a precursor for the (3S)-aryloxypyrrolidine fragment, which is used to construct key intermediates of FXa inhibitors (such as DX-9065a (HY-10722)) and various chiral drugs. (R)-(-)-N-Boc-3-pyrrolidinol can be applied in studies related to arrhythmia[1][2][3].
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(R)-(-)-N-Boc-3-pyrrolidinol | 99.99% | (R)-(-)-N-Boc-3-pyrrolidinol is a chiral pyrrolidine derivative. After undergoing configuration inversion via the Mitsunobu reaction, (R)-(-)-N-Boc-3-pyrrolidinol can serve as a precursor for the (3S)-aryloxypyrrolidine fragment, which is used to construct key intermediates of FXa inhibitors (such as DX-9065a (HY-10722)) and various chiral drugs. (R)-(-)-N-Boc-3-pyrrolidinol can be applied in studies related to arrhythmia. | ||||||||||||||||||||
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(R)-(-)-N-Boc-3-pyrrolidinol-d4 | (R)-(-)-N-Boc-3-pyrrolidinol-d4 is the d4-labeled (R)-(-)-N-Boc-3-pyrrolidinol (HY-W001294). (R)-(-)-N-Boc-3-pyrrolidinol is a chiral pyrrolidine derivative. After undergoing configuration inversion via the Mitsunobu reaction, (R)-(-)-N-Boc-3-pyrrolidinol can serve as a precursor for the (3S)-aryloxypyrrolidine fragment, which is used to construct key intermediates of FXa inhibitors (such as DX-9065a (HY-10722)) and various chiral drugs. (R)-(-)-N-Boc-3-pyrrolidinol can be applied in studies related to arrhythmia. | |||||||||||||||||||||
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References
- [1]. Elizabeth L.S. Cheu, et al. Pegylated ion channel modulating compounds. WO2005094897A2. WIPO (PCT). 2005-03-31.
- [2]. Nagahara T, et al. Dibasic (amidinoaryl)propanoic acid derivatives as novel blood coagulation factor Xa inhibitors. Journal of medicinal chemistry. 1994 Apr 15;37(8):1200-7. [Content Brief]
- [3]. Wang L, et al. Immobilization of growing Sphingomonas sp. HXN-200 to gelatin microspheres: efficient biotransformation of N-Cbz-pyrrolidine and N-Boc-pyrrolidine into hydroxypyrrolidine derivatives. Journal of biotechnology. 2014 Jul 20;182-183:74-82. [Content Brief]
