1095598-84-7
1095598-84-7
Chemical Structure
Darifenacin-d4
Synonym(s): UK-88525-d4
- CAS No.: 1095598-84-7
- Formula:C28H26D4N2O2
- Molecular Weight:430.57
IUPAC Name: (R)-3-((docosanoyl-1,2,3,4,5,6-13C6)oxy)-2-hydroxypropyl (2-(trimethylammonio)ethyl) phosphate
InChIKey: HXGBXQDTNZMWGS-JBAXBHDASA-N
SMILES: NC(C(C1=CC=CC=C1)(C2=CC=CC=C2)[C@H]3CN(CC3)C([2H])([2H])C([2H])([2H])C4=CC=C(OCC5)C5=C4)=O
Biological Activity: Darifenacin-d4 is the deuterium labeled Darifenacin[1]. Darifenacin(UK88525) is a selective M3 muscarinic receptor antagonist with pKi of 8.9. IC50 value: 8.9 (pKi)[2].
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Darifenacin-d4 | Darifenacin-d4 is the deuterium labeled Darifenacin. Darifenacin(UK88525) is a selective M3 muscarinic receptor antagonist with pKi of 8.9. IC50 value: 8.9 (pKi). | |||||||||||||||||||||
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Darifenacin | 99.81% | Darifenacin (UK-88525) is a selective and orally active M3 muscarinic receptor (M3R) antagonist with a pKi of 8.9. Darifenacin binds >20-fold more specifically to M3R than to other muscarinic receptors. Darifenacin can be used in the study of urinary incontinence and other symptoms of overactive bladder. Darifenacin inhibits tumor growth in colorectal cancer cells and has anti-tumor effects. | ||||||||||||||||||||
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References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [Content Brief]
- [2]. Hegde SS, et al. Functional role of M2 and M3 muscarinic receptors in the urinary bladder of rats in vitro and in vivo. Br J Pharmacol, 1997, 120(8), 1409-1418. [Content Brief]
Keywords
