110351-94-5
110351-94-5
Chemical Structure
Exatecan Intermediate 1
- CAS No.: 110351-94-5
- Formula:C13H13NO5
- Molecular Weight:263.25
IUPAC Name: (S)-4-ethyl-4-hydroxy-7,8-dihydro-1H-pyrano[3,4-f]indolizine-3,6,10(4H)-trione
InChIKey: IGKWOGMVAOYVSJ-ZDUSSCGKSA-N
SMILES: O=C1[C@](O)(CC)C(C=C23)=C(CO1)C(N3CCC2=O)=O
Biological Activity: Exatecan Intermediate 1 (compound 6) is an intermediate of Exatecan (HY-13631). Exatecan is a DNA topoisomerase I inhibitor with anticancer effects[1][2][3].
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Exatecan Intermediate 1 | 100.1% | Exatecan Intermediate 1 (compound 6) is an intermediate of Exatecan (HY-13631). Exatecan is a DNA topoisomerase I inhibitor with anticancer effects. | ||||||||||||||||||||
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Exatecan Intermediate 1 (Standard) | ≥98% | Exatecan Intermediate 1 (Standard) is the analytical standard of Exatecan Intermediate 1. This product is intended for research and analytical applications. Exatecan Intermediate 1 (compound 6) is an intermediate of Exatecan (HY-13631). Exatecan is a DNA topoisomerase I inhibitor with anticancer effects. | ||||||||||||||||||||
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Exatecan Intermediate 1-d2 | Exatecan Intermediate 1-d2 is the deuterium labeled Exatecan Intermediate 1 (HY-42487). Exatecan Intermediate 1 (compound 6) is an intermediate of Exatecan (HY-13631). Exatecan is a DNA topoisomerase I inhibitor with anticancer effects. | |||||||||||||||||||||
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Exatecan Intermediate 1-d5 | 99.90% | Exatecan Intermediate 1-d5 is the deuterium labeled Exatecan Intermediate 1. | ||||||||||||||||||||
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References
- [1]. Weng W, et al. Antibody-Exatecan Conjugates with a Novel Self-immolative Moiety Overcome Resistance in Colon and Lung Cancer. Cancer Discov. 2023 Apr 3;13(4):950-973. [Content Brief]
- [2]. Zhang Hongwei, et al. Intermediate for synthesizing camptothecin derivatives using exatecan mesylate and its preparation method and application. China, CN111470998. 2020-07-31.
- [3]. Conilh L, et al. Exatecan Antibody Drug Conjugates Based on a Hydrophilic Polysarcosine Drug-Linker Platform. Pharmaceuticals (Basel). 2021 Mar 9;14(3):247. [Content Brief]
