110874-36-7
110874-36-7
Chemical Structure
Enfipaxetan
Synonym(s): HOPO 14-1; 3,4,3-LI(1,2-HOPO)
- CAS No.: 110874-36-7
- Formula:C34H38N8O12
- Molecular Weight:750.71
InChIKey: KUWKQASGHNTJAT-UHFFFAOYSA-N
SMILES: O=C1C=CC=C(N1O)C(NCCCN(CCCCN(CCCNC(C2=CC=CC(N2O)=O)=O)C(C3=CC=CC(N3O)=O)=O)C(C4=CC=CC(N4O)=O)=O)=O
Biological Activity: Enfipaxetan (HOPO 14-1) is an orally active octadentate hydroxypyridinone chelating agent. Enfipaxetan chelates trivalent lanthanides through the hydroxypyridinone units of the spermine backbone, promoting the fecal excretion of europium[1][2][3][4][5].
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Enfipaxetan | Enfipaxetan (HOPO 14-1) is an orally active octadentate hydroxypyridinone chelating agent. Enfipaxetan chelates trivalent lanthanides through the hydroxypyridinone units of the spermine backbone, promoting the fecal excretion of europium. | |||||||||||||||||||||
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References
- [1]. Sturzbecher-Hoehne M, et al. 3,4,3-LI(1,2-HOPO): in vitro formation of highly stable lanthanide complexes translates into efficacious in vivo europium decorporation. Dalton transactions (Cambridge, England : 2003). 2011 Sep 07;40(33):8340-6. [Content Brief]
- [2]. Kelley MP, et al. Bond Covalency and Oxidation State of Actinide Ions Complexed with Therapeutic Chelating Agent 3,4,3-LI(1,2-HOPO). Inorganic chemistry. 2018 May 07;57(9):5352-5363. [Content Brief]
- [3]. Abergel RJ, et al. Biomimetic actinide chelators: an update on the preclinical development of the orally active hydroxypyridonate decorporation agents 3,4,3-LI(1,2-HOPO) and 5-LIO(Me-3,2-HOPO). Health physics. 2010 Sep;99(3):401-7. [Content Brief]
- [4]. Choi TA, et al. In vitro metabolism and stability of the actinide chelating agent 3,4,3-LI(1,2-HOPO). Journal of pharmaceutical sciences. 2015 May;104(5):1832-8.
- [5]. Wang Q, et al. Chelation Behaviors of 3,4,3-LI(1,2-HOPO) with Lanthanides and Actinides Implicated by Molecular Dynamics Simulations. Inorganic chemistry. 2023 Mar 13;62(10):4304-4313. [Content Brief]
