111130-14-4
Chemical Structure
CGP-33304 sodium
- CAS No.: 111130-14-4
- Formula:C23H25BrN5NaO5
- Molecular Weight:554.37
IUPAC Name: sodium 6-acetyl-3-(3-(2-bromo-4-methyl-5-(2H-tetrazole-5-carboxamido)phenoxy)propoxy)-2-propylphenolate
InChIKey: JTGPJWSJGGUZEA-UHFFFAOYSA-M
SMILES: O=C(C1=NNN=N1)NC2=CC(OCCCOC3=CC=C(C(C)=O)C(O[Na])=C3CCC)=C(Br)C=C2C
Biological Activity: CGP-33304 sodium is an antagonist of the leukotriene receptor and an inhibitor of phospholipase A2. CGP-33304 sodium inhibits the accumulation of myocardial depressant factor (MDF) activity in plasma and prolongs survival time in a standardized traumatic shock model of rats. CGP-33304 sodium can be applied in the research of traumatic shock[1][2].
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CGP-33304 sodium | CGP-33304 sodium is an antagonist of the leukotriene receptor and an inhibitor of phospholipase A2. CGP-33304 sodium inhibits the accumulation of myocardial depressant factor (MDF) activity in plasma and prolongs survival time in a standardized traumatic shock model of rats. CGP-33304 sodium can be applied in the research of traumatic shock. | |||||||||||||||||||||
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References
- [1]. Masamune, Hiroko et al. Novel Applications of leukotriene intervention. Annual Reports in Medicinal Chemistry. Vol. 24. Academic Press, 1989. 71-79.
- [2]. Levitt, M. A., et al. Efficacy of two leukotriene antagonists in rat traumatic shock. Methods and Findings in Experimental and Clinical Pharmacology 9.5 (1987): 269-273.
