1126-58-5
Chemical Structure
Girard's P reagent
- CAS No.: 1126-58-5
- Formula:C7H10ClN3O
- Molecular Weight:187.63
IUPAC Name: 1-(2-hydrazinyl-2-oxoethyl)pyridin-1-ium chloride
InChIKey: NDXLVXDHVHWYFR-UHFFFAOYSA-N
SMILES: O=C(NN)C[N+]1=CC=CC=C1.[Cl-]
Biological Activity: Girard's P reagent is a hydrazine-based carbonyl derivatization reagent containing a positively charged pyridine and a reactive acetylhydrazide, which can form a stable hydrazone with carbonyl groups. Girard's P reagent derivatizes protein carbonyls through hydrazone formation and through the acylhydrazide moiety forming a Schiff base that is subsequently reduced to a stable secondary amine. Girard's P reagent enhances the ionization efficiency for mass spectrometric detection and introduces a quaternary amine moiety that enhances the ionization of derivatized species. Girard's P reagent enables strong cation exchange enrichment of labeled peptides[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Girard's P reagent | 99.74% | Girard's P reagent is a hydrazine-based carbonyl derivatization reagent containing a positively charged pyridine and a reactive acetylhydrazide, which can form a stable hydrazone with carbonyl groups. Girard's P reagent derivatizes protein carbonyls through hydrazone formation and through the acylhydrazide moiety forming a Schiff base that is subsequently reduced to a stable secondary amine. Girard's P reagent enhances the ionization efficiency for mass spectrometric detection and introduces a quaternary amine moiety that enhances the ionization of derivatized species. Girard's P reagent enables strong cation exchange enrichment of labeled peptides. | ||||||||||||||||||||
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Girard's Reagent P-d5 | 99.9% | Girard's Reagent P-d5 is the d5-labeled Girard's P reagent (HY-W077680). Girard's P reagent is a hydrazine-based carbonyl derivatization reagent containing a positively charged pyridine and a reactive acetylhydrazide, which can form a stable hydrazone with carbonyl groups. Girard's P reagent derivatizes protein carbonyls through hydrazone formation and through the acylhydrazide moiety forming a Schiff base that is subsequently reduced to a stable secondary amine. Girard's P reagent enhances the ionization efficiency for mass spectrometric detection and introduces a quaternary amine moiety that enhances the ionization of derivatized species. Girard's P reagent enables strong cation exchange enrichment of labeled peptides. | ||||||||||||||||||||
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Similarity Score 0.97
HY-146772S1-(2-Hydrazinyl-2-oxoethyl)pyridin-1-ium-d5 bromide -
Similarity Score 0.75
HY-B0329SIsoniazid-d4 -
Similarity Score 0.74
HY-W701397Nicotinamide N-oxide-d4 -
Similarity Score 0.74
HY-W698938Pyridine N-oxide-d5 -
Similarity Score 0.73
HY-167931Cinnamohydrazide -
Similarity Score 0.72
HY-W016825S12-(Pyridin-2-yl)acetic acid-d4 hydrochloride -
Similarity Score 0.71
HY-W012843SIsonicotinamide-d4 -
Similarity Score 0.70
HY-B0150SNicotinamide-d4 -
Similarity Score 0.70
HY-W014837NDSB-201 -
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References
- [1]. Harkin C, et al. On-tissue chemical derivatization in mass spectrometry imaging. Mass spectrometry reviews. 2022 Sep;41(5):662-694. [Content Brief]
- [2]. Yang Y. Site-Specific Characterization of Oxidative Carbonylation on Recombinant Monoclonal Antibodies (Doctoral dissertation, et al. [Content Brief]
- [3]. Smith J, et al. Quantitative glycomics using liquid phase separations coupled to mass spectrometry. The Analyst. 2017 Feb 27;142(5):700-720. [Content Brief]
- [4]. Mirzaei H, et al. Identification and quantification of protein carbonylation using light and heavy isotope labeled Girard's P reagent. Journal of chromatography. A. 2006 Nov 17;1134(1-2):122-33. [Content Brief]
