113165-32-5
Chemical Structure
(+)-Niguldipine
- CAS No.: 113165-32-5
- Formula:C36H39N3O6
- Molecular Weight:609.71
IUPAC Name: 3-(3-(4,4-diphenylpiperidin-1-yl)propyl) 5-methyl (S)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
InChIKey: SVJMLYUFVDMUHP-XIFFEERXSA-N
SMILES: O=C(C1=C(C)NC(C)=C(C(OC)=O)[C@@H]1C2=CC=CC([N+]([O-])=O)=C2)OCCCN3CCC(C4=CC=CC=C4)(C5=CC=CC=C5)CC3
Biological Activity: (+)-Niguldipine is a potent dual inhibitor targeting L-type Ca2+ channels (Ki=85 pM) and α₁-adrenoceptor (Ki=52 pM). (+)-Niguldipine is promising for research of hypertension and cardiovascular diseases[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
(+)-Niguldipine | (+)-Niguldipine is a potent dual inhibitor targeting L-type Ca2+ channels (Ki=85 pM) and α₁-adrenoceptor (Ki=52 pM). (+)-Niguldipine is promising for research of hypertension and cardiovascular diseases. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Boer R, et al. (+)-Niguldipine binds with very high affinity to Ca2+ channels and to a subtype of α1-adrenoceptors[J]. European Journal of Pharmacology: Molecular Pharmacology, 1989, 172(2): 131-145. [Content Brief]
- [2]. Endoh M, et al. Effect of (+)-niguldipine on myocardial α1-adrenoceptors in the rabbit[J]. European journal of pharmacology, 1992, 223(2-3): 143-149.
- [3]. Charles Gluchowski, et al. Use of alpha-1c specific compounds to treat benign prostatic hyperplasia. WO1995028157A1. 1995-10-26.
Keywords
