115369-52-3
Chemical Structure
ME-1228
- CAS No.: 115369-52-3
- Formula:C23H24N6O7S3
- Molecular Weight:592.67
IUPAC Name: (6R,7R)-7-((Z)-2-(2-aminothiazol-4-yl)-2-(((S)-1-carboxyethoxy)imino)acetamido)-3-(((1-ethylpyridin-1-ium-4-yl)thio)methyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
InChIKey: HJXPKHCLLLRQDL-SZDZOZPASA-N
SMILES: [O-]C(C1=C(CSC2=CC=[N+](CC)C=C2)CS[C@@]([C@@H]3NC(/C(C4=CSC(N)=N4)=N\O[C@@H](C)C(O)=O)=O)([H])N1C3=O)=O
Biological Activity: ME-1228 is an antibacterial agent and sulfur-containing analogue of OCP 9-176. ME 1228 is generally twofold more active than OCP 9-176 against Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Providencia stuartii, Proteus vulgaris, and Serratia marcescens. ME-1228 has antibacterial activity against E. coli UB 1005, P. aeruginosa K779K, and P. aeruginosa E4, with MICs of 0.25, 0.25, and 1 μg/mL, respectively[1].
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ME-1228 | ME-1228 is an antibacterial agent and sulfur-containing analogue of OCP 9-176. ME 1228 is generally twofold more active than OCP 9-176 against Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, Providencia stuartii, Proteus vulgaris, and Serratia marcescens. ME-1228 has antibacterial activity against E. coli UB 1005, P. aeruginosa K779K, and P. aeruginosa E4, with MICs of 0.25, 0.25, and 1 μg/mL, respectively. | |||||||||||||||||||||
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Keywords
