115722-78-6
115722-78-6
Chemical Structure
N-Acetoxy-IQ
- CAS No.: 115722-78-6
- Formula:C13H12N4O2
- Molecular Weight:256.26
InChIKey: ZNLLBBZONQYLII-UHFFFAOYSA-N
SMILES: O=C(C)O/N=C1NC2=C(N/1C)C=CC3=NC=CC=C23
Biological Activity: N-Acetoxy-IQ is a DNA alkylating agent that can covalently bind to DNA, especially guanine residues. N-Acetoxy-IQ exerts mutagenic and carcinogenic activities by forming DNA adducts. N-Acetoxy-IQ is promising for research of cancers[1][2][3].
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N-Acetoxy-IQ | N-Acetoxy-IQ is a DNA alkylating agent that can covalently bind to DNA, especially guanine residues. N-Acetoxy-IQ exerts mutagenic and carcinogenic activities by forming DNA adducts. N-Acetoxy-IQ is promising for research of cancers. | |||||||||||||||||||||
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References
- [1]. Schut HA, et al. Similar patterns of DNA adduct formation of 2-amino-3-methylimidazo [4,5-f]quinoline in the Fischer 344 rat, CDF1 mouse, cynomolgus monkey and Salmonella typhimurium. Carcinogenesis. 1991 May;12(5):931-4. [Content Brief]
- [2]. Turesky RJ, et al. Formation and persistence of DNA adducts of 2-amino-3-methylimidazo[4,5-f]quinoline in the rat and nonhuman primates. Mutat Res. 1997 May 12;376(1-2):235-41. [Content Brief]
- [3]. Turesky RJ, et al. DNA adduct formation of the food carcinogen 2-amino-3-methylimidazo[4,5- f]quinoline at the C-8 and N2 atoms of guanine. Chem Res Toxicol. 1994 Nov-Dec;7(6):752-61. [Content Brief]
