1162658-64-1
Chemical Structure
AZD3783
- CAS No.: 1162658-64-1
- Formula:C26H34N4O4
- Molecular Weight:466.57
InChIKey: SKOWCFJEXPLGNE-XMMPIXPASA-N
SMILES: O=C([C@@H]1OC2=C(N3CCN(CC3)C)C=C(C=C2CC1)OC)NC4=CC=C(N5CCOCC5)C=C4
Biological Activity: AZD3783 is an orally active, blood-brain barrier-penetrant 5-HT1B receptor antagonist. AZD3783 reverses agonist-induced hypothermia, inhibits separation-induced vocalizations in guinea pig pups, and acts as a moderately permeable glycoprotein substrate with moderate clearance. AZD3783 inhibits hERG channel activity. AZD3783 is applicable for research on depression, anxiety disorders, and other psychiatric diseases associated with serotonergic neurotransmission[1][2].
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AZD3783 | AZD3783 is an orally active, blood-brain barrier-penetrant 5-HT1B receptor antagonist. AZD3783 reverses agonist-induced hypothermia, inhibits separation-induced vocalizations in guinea pig pups, and acts as a moderately permeable glycoprotein substrate with moderate clearance. AZD3783 inhibits hERG channel activity. AZD3783 is applicable for research on depression, anxiety disorders, and other psychiatric diseases associated with serotonergic neurotransmission. | |||||||||||||||||||||
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- [1]. Nugiel DA, et al. De novo design of a picomolar nonbasic 5-HT(1B) receptor antagonist. J Med Chem. 2010 Feb 25;53(4):1876-80. [Content Brief]
- [2]. Zhang M, et al. Preclinical pharmacology and pharmacokinetics of AZD3783, a selective 5-hydroxytryptamine 1B receptor antagonist. J Pharmacol Exp Ther. 2011;339(2):567-578. [Content Brief]
Keywords
