116430-80-9
Chemical Structure
KRDS
Synonym(s): Lys-Arg-Asp-Ser
- CAS No.: 116430-80-9
- Formula:C19H36N8O8
- Molecular Weight:504.54
IUPAC Name: (S)-4-(((S)-1-carboxy-2-hydroxyethyl)amino)-3-((S)-2-((S)-2,6-diaminohexanamido)-5-guanidinopentanamido)-4-oxobutanoic acid
InChIKey: UIQDLWNRJRTKJV-CYDGBPFRSA-N
SMILES: NCCCC[C@H](N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(O)=O)C(N[C@@H](CO)C(O)=O)=O)=O)=O
Biological Activity: KRDS (Lys-Arg-Asp-Ser) is a polypeptide. KRDS can be derived from Lactoferrin (HY-NP023) (corresponding to residues 39-42 of h-Lactoferrin). KRDS inhibits the binding of the monoclonal antibodies AP2 and P2 targeting GP IIb-IIIa to ADP-stimulated washed platelets. KRDS inhibits the binding of fibrinogen to stimulated platelets. KRDS inhibits platelet aggregation. KRDS, when combined with RGDS, produces a synergistic antithrombotic effect in an animal model of laser-induced arteriolar thrombosis. KRDS promotes the production of neurotrophic factors, growth-associated proteins, and pro-inflammatory cytokines in the early stage of nerve regeneration. KRDS, when incorporated into collagen tubes, supports early regeneration of injured rat sciatic nerve and the formation of myelinated nerve fibers[1][2][3].
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KRDS | KRDS (Lys-Arg-Asp-Ser) is a polypeptide. KRDS can be derived from Lactoferrin (HY-NP023) (corresponding to residues 39-42 of h-Lactoferrin). KRDS inhibits the binding of the monoclonal antibodies AP2 and P2 targeting GP IIb-IIIa to ADP-stimulated washed platelets. KRDS inhibits the binding of fibrinogen to stimulated platelets. KRDS inhibits platelet aggregation. KRDS, when combined with RGDS, produces a synergistic antithrombotic effect in an animal model of laser-induced arteriolar thrombosis. KRDS promotes the production of neurotrophic factors, growth-associated proteins, and pro-inflammatory cytokines in the early stage of nerve regeneration. KRDS, when incorporated into collagen tubes, supports early regeneration of injured rat sciatic nerve and the formation of myelinated nerve fibers. | |||||||||||||||||||||
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References
- [1]. Raha S, et al. KRDS--a tetrapeptide derived from lactotransferrin--inhibits binding of monoclonal antibody against glycoprotein IIb-IIIa on ADP-stimulated platelets and megakaryocytes. Blood. 1988 Jul;72(1):172-8.
- [2]. Mazoyer E, et al. KRDS, a new peptide derived from human lactotransferrin, inhibits platelet aggregation and release reaction. European journal of biochemistry. 1990 Nov 26;194(1):43-9.
- [3]. Ahmed MR, et al. Initial upregulation of growth factors and inflammatory mediators during nerve regeneration in the presence of cell adhesive peptide-incorporated collagen tubes. Journal of the peripheral nervous system : JPNS. 2005 Mar;10(1):17-30.
