1184264-15-0
1184264-15-0
Chemical Structure
Lapatinib-d4-1
Synonym(s): GW572016-d4-1;GW2016-d4-1
- CAS No.: 1184264-15-0
- Formula:C29H22D4ClFN4O4S
- Molecular Weight:585.08
IUPAC Name: 3-(9,10-ethanoanthracen-9(10H)-yl)-N-(methyl-d3)propan-1-amine hydrochloride
InChIKey: BCFGMOOMADDAQU-XODZCWLCSA-N
SMILES: CS(CCNCC1=CC=C(O1)C2=CC(C(NC3=CC(Cl)=C(C=C3)OCC4=C([2H])C(F)=C([2H])C([2H])=C4[2H])=NC=N5)=C5C=C2)(=O)=O
Biological Activity: Lapatinib-d4-1 is deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively[1].
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Lapatinib-d4-1 | Lapatinib-d4-1 is deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively. | |||||||||||||||||||||
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Lapatinib (Standard) | 99.69% | Lapatinib (Standard) is the analytical standard of Lapatinib. This product is intended for research and analytical applications. Lapatinib (GW572016) is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively. | ||||||||||||||||||||
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Lapatinib-d4 | 99.02% | Lapatinib-d4 is the deuterium labeled Lapatinib (HY-50898). Lapatinib is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively. | ||||||||||||||||||||
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Lapatinib-d5 | Lapatinib-d5 is deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively. | |||||||||||||||||||||
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Lapatinib-d7 dihydrochloride | Lapatinib-d7 dihydrochloride is the deuterium labeled Lapatinib dihydrochloride. Lapatinib (GW572016) dihydrochloride is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively. | |||||||||||||||||||||
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Lapatinib-13C,d7 | Lapatinib-13C,d7 (GW572016-13C,d7) is the deuterium and 13C-labeled Lapatinib (HY-50898). Lapatinib (GW572016) is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively. | |||||||||||||||||||||
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Lapatinib-d7 | Lapatinib-d7 (GW572016-d7) is deuterium labeled Lapatinib. Lapatinib (GW572016) is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively. | |||||||||||||||||||||
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Lapatinib | 99.83% | Lapatinib (GW572016) is a potent, orally active inhibitor of the ErbB-2 and EGFR tyrosine kinase domains with IC50 values against purified EGFR and ErbB-2 of 10.2 and 9.8 nM, respectively. | ||||||||||||||||||||
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References
