1185136-22-4
1185136-22-4
Chemical Structure
LP 12 hydrochloride
- CAS No.: 1185136-22-4
- Formula:C32H40ClN3O
- Molecular Weight:518.13
IUPAC Name: 6-(4-([1,1'-biphenyl]-2-yl)piperazin-1-yl)-N-(1,2,3,4-tetrahydronaphthalen-1-yl)hexanamide hydrochloride
InChIKey: XNDUOTNYUWDFKR-UHFFFAOYSA-N
SMILES: O=C(NC1CCCC2=C1C=CC=C2)CCCCCN3CCN(C4=CC=CC=C4C5=CC=CC=C5)CC3.[H]Cl
Biological Activity: LP 12 hydrochloride (compound 21) is a potent and selective 5-HT7 receptor agonist with a Ki of 0.13 nM. LP 12 hydrochloride displays selectivity for 5-HT7 over D2, 5-HT1A and 5-HT2A receptors (Ki values are 224 nM, 60.9 nM and >1000 nM, respectively)[1][2].
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LP 12 hydrochloride | LP 12 hydrochloride (compound 21) is a potent and selective 5-HT7 receptor agonist with a Ki of 0.13 nM. LP 12 hydrochloride displays selectivity for 5-HT7 over D2, 5-HT1A and 5-HT2A receptors (Ki values are 224 nM, 60.9 nM and >1000 nM, respectively). | |||||||||||||||||||||
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References
- [1]. Marcello Leopoldo, et al. Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. J Med Chem. 2007 Aug 23;50(17):4214-21. [Content Brief]
- [2]. Sugiyama Y, et, al. Effects of 5-hydroxytryptamine on spermatozoal hyperactivation and in vitro fertilization in mice. J Reprod Dev. 2019 Dec 18;65(6):541-550. [Content Brief]
