118524-14-4
Chemical Structure
Licocoumarone
- CAS No.: 118524-14-4
- Formula:C20H20O5
- Molecular Weight:340.37
InChIKey: CNPMAFLUEHEXRE-UHFFFAOYSA-N
SMILES: OC1=CC(O)=C(C2=CC3=C(C=C(C(C/C=C(C)\C)=C3OC)O)O2)C=C1
Biological Activity: Licocoumarone is an active component derived from licorice. Licocoumarone has an IC50 of 12.56 μM and a Kd of 14.90 μM against human DYRK1A. Licocoumarone inhibits NF-κB activation by blocking IκBα degradation and p65 phosphorylation, interferes with MAPK activation via inhibiting phosphorylation, and downregulates the expression of iNOS. Licocoumarone inhibits LPS-induced expression of IL-1β, IL-6 and IL-10; it induces apoptosis of pancreatic cancer cells apoptosis and acts as a neuraminidase inhibitor (IC50 = 27.8 μM). Licocoumarone exhibits anti-inflammatory and antimicrobial activities, with antibacterial activity against Listeria and antifungal activity against Candida parapsilosis. Licocoumarone can be used in studies related to immune and inflammatory diseases, pancreatic cancer, and specific bacterial and fungal infections[1][2][3][4].
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Licocoumarone | Licocoumarone is an active component derived from licorice. Licocoumarone has an IC50 of 12.56 μM and a Kd of 14.90 μM against human DYRK1A. Licocoumarone inhibits NF-κB activation by blocking IκBα degradation and p65 phosphorylation, interferes with MAPK activation via inhibiting phosphorylation, and downregulates the expression of iNOS. Licocoumarone inhibits LPS-induced expression of IL-1β, IL-6 and IL-10; it induces apoptosis of pancreatic cancer cells apoptosis and acts as a neuraminidase inhibitor (IC50 = 27.8 μM). Licocoumarone exhibits anti-inflammatory and antimicrobial activities, with antibacterial activity against Listeria and antifungal activity against Candida parapsilosis. Licocoumarone can be used in studies related to immune and inflammatory diseases, pancreatic cancer, and specific bacterial and fungal infections. | |||||||||||||||||||||
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- [1]. Wu L H, et al. Licocoumarone isolated from Glycyrrhiza uralensis selectively alters LPS-induced inflammatory responses in RAW 264.7 macrophages. European Journal of Pharmacology, 2017, 801: 46-53.
- [2]. Zhao C, et al. Licocoumarone induces BxPC-3 pancreatic adenocarcinoma cell death by inhibiting DYRK1A. Chemico-biological interactions. 2020 Jan 25;316:108913. [Content Brief]
- [3]. Ryu YB, et al. Inhibition of neuraminidase activity by polyphenol compounds isolated from the roots of Glycyrrhiza uralensis. Bioorganic & medicinal chemistry letters. 2010 Feb 01;20(3):971-4. [Content Brief]
- [4]. Çevik D, et al. Evaluation of antimicrobial and antibiofilm activities of secondary metabolites isolated from Glycyrrhiza species. South African Journal of Botany, 2026, 196: 662-673.
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