1186229-95-7
Chemical Structure
Lu AE51090
- CAS No.: 1186229-95-7
- Formula:C24H29N3O3
- Molecular Weight:407.51
IUPAC Name: N-(1-(3-(3-oxo-2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)propyl)piperidin-4-yl)-2-phenylacetamide
InChIKey: FLGSUSWMWSZVMP-UHFFFAOYSA-N
SMILES: O=C(NC1CCN(CCCN2C3=CC=CC=C3OCC2=O)CC1)CC4=CC=CC=C4
Biological Activity: Lu AE51090 is selective muscarinic M1 receptor agonist with blood-brain barrier penetration. Lu AE51090 activates human M1 receptor with EC50 of 61 nM, while showing no significant agonism at M2-M5 receptors. Lu AE51090 exerts procognitive effects in mice. Lu AE51090 can be used for the study of Alzheimer’s disease (AD) and cognitive impairment associated with schizophrenia (CIAS)[1].
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Lu AE51090 | 99.51% | Lu AE51090 is selective muscarinic M1 receptor agonist with blood-brain barrier penetration. Lu AE51090 activates human M1 receptor with EC50 of 61 nM, while showing no significant agonism at M2-M5 receptors. Lu AE51090 exerts procognitive effects in mice. Lu AE51090 can be used for the study of Alzheimer’s disease (AD) and cognitive impairment associated with schizophrenia (CIAS). | ||||||||||||||||||||
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Keywords
