1189477-66-4
1189477-66-4
Chemical Structure
Nilutamide-d6
- CAS No.: 1189477-66-4
- Formula:C12H4D6F3N3O4
- Molecular Weight:323.26
IUPAC Name: 5,5-bis(methyl-d3)-3-(4-nitro-3-(trifluoromethyl)phenyl)imidazolidine-2,4-dione
InChIKey: XWXYUMMDTVBTOU-WFGJKAKNSA-N
SMILES: O=C1N(C2=CC(C(F)(F)F)=C(C=C2)[N+]([O-])=O)C(NC1(C([2H])([2H])[2H])C([2H])([2H])[2H])=O
Biological Activity: Nilutamide-d6 (Nilandron-d6) is the deuterium labeled Nilutamide. Nilutamide (Nilandron) is a non-steroidal anti-androgen agent proposed in the research of metastatic prostatic carcinoma[1][2].
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Nilutamide-d6 | 99.77% | Nilutamide-d6 (Nilandron-d6) is the deuterium labeled Nilutamide. Nilutamide (Nilandron) is a non-steroidal anti-androgen agent proposed in the research of metastatic prostatic carcinoma. | ||||||||||||||||||||
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Nilutamide (Standard) | ≥98% | Nilutamide (Standard) is the analytical standard of Nilutamide. This product is intended for research and analytical applications. Nilutamide (Nilandron) is an orally active nonsteroidal androgen receptor antagonist with affinity for androgen receptors but not for progestogen, estrogen or glucocorticoid receptors. Nilutamide can be used to research prostate cancer. Nilutamide also has antischistosomal properties. | ||||||||||||||||||||
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Nilutamide | 99.74% | Nilutamide (Nilandron) is an orally active nonsteroidal androgen receptor antagonist with affinity for androgen receptors but not for progestogen, estrogen or glucocorticoid receptors. Nilutamide can be used to research prostate cancer. Nilutamide also has antischistosomal properties. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.81
HY-W054427Ro 13-3978 -
Similarity Score 0.79
HY-77833RU 56279 -
Similarity Score 0.67
HY-120703RU 58642 -
Similarity Score 0.63
HY-B0022Flutamide -
Similarity Score 0.63
HY-117486RU 56187 -
Similarity Score 0.63
HY-W011958RN-(4-Nitro-3-(trifluoromethyl)phenyl)acetamide (Standard) -
Similarity Score 0.62
HY-W013272Hydroxyflutamide -
Similarity Score 0.62
HY-168547SAR89-d6 -
Similarity Score 0.56
HY-10561RRU 58841 (Standard) -
Explore the MedChemAI to find more analogs
References
- [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
- [2]. Harris MG, et al. Nilutamide. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in prostate cancer. Drugs Aging. 1993 Jan-Feb;3(1):9-25. [Content Brief]
