1189732-75-9
Chemical Structure
Olanzapine N-Oxide-d3
- CAS No.: 1189732-75-9
- Formula:C17H17D3N4OS
- Molecular Weight:331.45
IUPAC Name: 1-(methyl-d3)-4-(2-methyl-10H-benzo[b]thieno[2,3-e][1,4]diazepin-4-yl)piperazine 1-oxide
InChIKey: LJVNYCDXBXGQIK-BMSJAHLVSA-N
SMILES: CC1=CC2=C(S1)NC3=CC=CC=C3N=C2N4CC[N+]([O-])(CC4)C([2H])([2H])[2H]
Biological Activity: Olanzapine N-Oxide-d3 is the d3-labeled Olanzapine N-oxide (HY-119393). Olanzapine N-oxide is a phase I metabolite of Olanzapine (HY-14541). Olanzapine N-oxide serves as a substrate for reduction reactions and converts to Olanzapine in whole blood in vitro. Olanzapine is an antipsychotic compound widely used in research on schizophrenia and other psychotic disorders[1][2].
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Olanzapine N-Oxide-d3 | Olanzapine N-Oxide-d3 is the d3-labeled Olanzapine N-oxide (HY-119393). Olanzapine N-oxide is a phase I metabolite of Olanzapine (HY-14541). Olanzapine N-oxide serves as a substrate for reduction reactions and converts to Olanzapine in whole blood in vitro. Olanzapine is an antipsychotic compound widely used in research on schizophrenia and other psychotic disorders. | |||||||||||||||||||||
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Olanzapine N-oxide | 98.72% | Olanzapine N-oxide is a phase I metabolite of Olanzapine (HY-14541). Olanzapine N-oxide serves as a substrate for reduction reactions and converts to Olanzapine in whole blood in vitro. Olanzapine is an antipsychotic compound widely used in research on schizophrenia and other psychotic disorders. | ||||||||||||||||||||
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References
- [1]. Okubo M, et al. Individual differences in in vitro and in vivo metabolic clearances of the antipsychotic drug olanzapine from non-smoking and smoking Japanese subjects genotyped for cytochrome P4502D6 and flavincontaining monooxygenase 3. Human psychopharmacology. 2016 Mar;31(2):83-92. [Content Brief]
- [2]. Nozawa H, et al. Quantification of olanzapine and its three metabolites by liquid chromatography-tandem mass spectrometry in human body fluids obtained from four deceased, and confirmation of the reduction from olanzapine N-oxide to olanzapine in whole blood in vitro. Forensic toxicology. 2023 Jul;41(2):318-328.
