119386-96-8
Chemical Structure
Mofegiline
Synonym(s): MDL-72974
- CAS No.: 119386-96-8
- Formula:C11H13F2N
- Molecular Weight:197.23
IUPAC Name: (E)-2-(fluoromethylene)-4-(4-fluorophenyl)butan-1-amine
InChIKey: VXLBSYHAEKDUSU-JXMROGBWSA-N
SMILES: C(C/C(=C\F)/CN)C1=CC=C(F)C=C1
Biological Activity: Mofegiline (MDL-72974) is an orally active and blood-brain barrier-penetrant MAO-B/SSAO selective inhibitor, with an IC50 of 3.6 nM for MAO-B and 10 nM for SSAO. Mofegiline is a cationic amphiphilic compound that can induce indirect sympathomimetic effects, lysosomal accumulation, hERG channel interactions, phospholipidosis, and cell death. Mofegiline protects mice from MPTP-induced depletion of striatal dopamine, DOPAC, and HVA. Mofegiline can be used in research related to Parkinson's disease[1][2][3].
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Mofegiline | Mofegiline (MDL-72974) is an orally active and blood-brain barrier-penetrant MAO-B/SSAO selective inhibitor, with an IC50 of 3.6 nM for MAO-B and 10 nM for SSAO. Mofegiline is a cationic amphiphilic compound that can induce indirect sympathomimetic effects, lysosomal accumulation, hERG channel interactions, phospholipidosis, and cell death. Mofegiline protects mice from MPTP-induced depletion of striatal dopamine, DOPAC, and HVA. Mofegiline can be used in research related to Parkinson's disease. | |||||||||||||||||||||
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References
- [1]. Zreika M, et al. MDL 72,974: a potent and selective enzyme-activated irreversible inhibitor of monoamine oxidase type B with potential for use in Parkinson's disease. Journal of neural transmission. Parkinson's disease and dementia section. 1989;1(4):243-54. [Content Brief]
- [2]. Foot JS, et al. Combining monoamine oxidase B and semicarbazide-sensitive amine oxidase enzyme inhibition to address inflammatory disease. Bioorganic & medicinal chemistry letters. 2022 Oct 15;74:128942.
- [3]. Clow A, et al. The effect of pergolide and MDL 72974 on rat brain CuZn superoxide dismutase. Neuroscience letters. 1993 Dec 24;164(1-2):41-3.
