1195779-24-8
1195779-24-8
Chemical Structure
T-1840383
- CAS No.: 1195779-24-8
- Formula:C30H25ClFN5O4
- Molecular Weight:574.00
IUPAC Name: N-(4-((2-(cyclopropanecarboxamido)imidazo[1,2-a]pyridin-6-yl)oxy)-3-fluorophenyl)-6-methyl-2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxamide hydrochloride
InChIKey: OJYDTTFFDHJUIB-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(C(F)=C1)OC2=CN3C(C=C2)=NC(NC(C4CC4)=O)=C3)C5=CC=C(N(C5=O)C6=CC=CC=C6)C.Cl
Biological Activity: T-1840383 is a potent, ATP-competitive inhibitor of c-Met/VEGFR-2, with the IC50s of 1.9 nM, 7.7 nM, 2.2 nM and 5.5 nM for c-Met, VEGFR1, VEGFR2 and VEGFR3, respectively[1].
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T-1840383 | T-1840383 is a potent, ATP-competitive inhibitor of c-Met/VEGFR-2, with the IC50s of 1.9 nM, 7.7 nM, 2.2 nM and 5.5 nM for c-Met, VEGFR1, VEGFR2 and VEGFR3, respectively. | |||||||||||||||||||||
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References
Keywords
