T-1840383
T-1840383 is a potent, ATP-competitive inhibitor of c-Met/VEGFR-2, with the IC50s of 1.9 nM, 7.7 nM, 2.2 nM and 5.5 nM for c-Met, VEGFR1, VEGFR2 and VEGFR3, respectively.
For research use only. We do not sell to patients.
- CAS No.: 1195779-24-8
- Formula: C30H25ClFN5O4
- Molecular Weight:574.00
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All VEGFR Isoforms
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HUVEC | IC50 |
1.8 nM
Compound: 26
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Cytotoxicity against VEGF-stimulated HUVEC assessed as growth inhibition after 120 hrs by CCK-8 assay
Cytotoxicity against VEGF-stimulated HUVEC assessed as growth inhibition after 120 hrs by CCK-8 assay
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[PMID: 24216091] |
| MKN-45 | IC50 |
5 nM
Compound: 26
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Cytotoxicity against human MKN45 cells assessed as growth inhibition after 72 hrs by CCK-8 assay
Cytotoxicity against human MKN45 cells assessed as growth inhibition after 72 hrs by CCK-8 assay
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[PMID: 24216091] |
Chemical Information
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CAS No. 1195779-24-8
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Molecular Weight 574.00
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Formula C30H25ClFN5O4
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SMILES
O=C(NC1=CC=C(C(F)=C1)OC2=CN3C(C=C2)=NC(NC(C4CC4)=O)=C3)C5=CC=C(N(C5=O)C6=CC=CC=C6)C.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
T-1840383 Related Classifications
HY-120661 Related Classifications
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