121377-67-1
121377-67-1
Chemical Structure
Endothelin (16-21)
- CAS 番号: 121377-67-1
- Formula:C39H57N9O9
- Molecular Weight:795.92
InChIKey: NTSBFTNRWQVBCA-IVGDYKFASA-N
SMILES: N[C@@H](CC1=CN=CN1)C(N[C@@H](CC(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H]([C@@H](C)CC)C(N[C@@H]([C@@H](C)CC)C(N[C@H](C(O)=O)CC2=CNC3=CC=CC=C23)=O)=O)=O)=O)=O
Biological Activity: Endothelin (16-21) is a selective ETB receptor agonist (EC50=228 nM in guinea-pig bronchus). Endothelin (16-21) can induce smooth muscle contraction. Endothelin (16-21) is promising for research of respiratory (e.g., asthma) and cardiovascular (e.g., hypertension) diseases[1][2].
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Endothelin (16-21) | Endothelin (16-21) is a selective ETB receptor agonist (EC50=228 nM in guinea-pig bronchus). Endothelin (16-21) can induce smooth muscle contraction. Endothelin (16-21) is promising for research of respiratory (e.g., asthma) and cardiovascular (e.g., hypertension) diseases. | |||||||||||||||||||||
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References
- [1]. Maggi CA, et al. The C-terminal hexapeptide, endothelin-(16-21), discriminates between different endothelin receptors. Eur J Pharmacol. 1989 Jul 4;166(1):121-2. [Content Brief]
- [2]. Douglas SA, et al. Endothelium-dependent mesenteric vasorelaxant effects and systemic actions of endothelin (16-21) and other endothelin-related peptides in the rat. Br J Pharmacol. 1991 Oct;104(2):311-20. [Content Brief]
