1217476-81-7
Chemical Structure
3-Acetyldeoxynivalenol-13C17
Synonym(s): 3-AcDON-13C17; 3-ADON-13C17
- CAS No.: 1217476-81-7
- Formula:13C17H22O7
- Molecular Weight:355.23
IUPAC Name: (2S,2'R,3'R,5'R,5a'R,6'S,9a'R)-6'-hydroxy-5a'-(hydroxymethyl-13C)-5',8'-di(methyl-13C)-7'-oxo-2',3',4',5',5a',6',7',9a'-octahydrospiro[oxirane-2,10'-[2,5]methanobenzo[b]oxepin]-3'-yl-2,2',3,3',4',5',5a',6',7',8',9',9a'-13C12 acetate-13C2
InChIKey: ADFIQZBYNGPCGY-CJTIMMQGSA-N
SMILES: [13CH3][13C@]12[13C@@]3([13C@@]([H])([13C@H](O[13C]([13CH3])=O)[13CH2]2)O[13C@]4([13C@]1([13CH2]O)[13C@H](O)[13C]([13C]([13CH3])=[13CH]4)=O)[H])[13CH2]O3
Biological Activity: 3-Acetyldeoxynivalenol (3-AcDON; 3ADON)-13C17 is the 13C labeled 3-Acetyldeoxynivalenol (HY-N6685). 3-Acetyldeoxynivalenol, a trichothecene mycotoxin deoxynivalenol (DON) acetylated derivative, is a brain-penetrant Fusarium mycotoxin. 3-Acetyldeoxynivalenol induces mRNA expression and production of inflammatory chemokine IL-8 in intestinal cells[1][2].
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3-Acetyldeoxynivalenol-13C17 | 99.0% | 3-Acetyldeoxynivalenol (3-AcDON; 3ADON)-13C17 is the 13C labeled 3-Acetyldeoxynivalenol (HY-N6685). 3-Acetyldeoxynivalenol, a trichothecene mycotoxin deoxynivalenol (DON) acetylated derivative, is a brain-penetrant Fusarium mycotoxin. 3-Acetyldeoxynivalenol induces mRNA expression and production of inflammatory chemokine IL-8 in intestinal cells. | ||||||||||||||||||||
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3-Acetyldeoxynivalenol (Standard) | ≥98% | 3-Acetyldeoxynivalenol (3-AcDON; 3ADON) (Standard) is the analytical standard of 3-Acetyldeoxynivalenol (HY-N6685). This product is intended for research and analytical applications. 3-Acetyldeoxynivalenol, a trichothecene mycotoxin deoxynivalenol (DON) acetylated derivative, is a brain-penetrant Fusarium mycotoxin. 3-Acetyldeoxynivalenol induces mRNA expression and production of inflammatory chemokine IL-8 in intestinal cells. | ||||||||||||||||||||
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3-Acetyldeoxynivalenol | 98.38% | 3-Acetyldeoxynivalenol (3-AcDON; 3ADON), a trichothecene mycotoxin deoxynivalenol (DON) acetylated derivative, is a brain-penetrant Fusarium mycotoxin. 3-Acetyldeoxynivalenol induces mRNA expression and production of inflammatory chemokine IL-8 in intestinal cells. | ||||||||||||||||||||
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- [1]. Kadota T, et al. Comparative study of deoxynivalenol, 3-acetyldeoxynivalenol, and 15-acetyldeoxynivalenolon intestinal transport and IL-8 secretion in the human cell line Caco-2. Toxicol In Vitro. 2013 Sep;27(6):1888-95. [Content Brief]
- [2]. Behrens M, et al. Blood-Brain Barrier Effects of the Fusarium Mycotoxins Deoxynivalenol, 3Acetyldeoxynivalenol, and Moniliformin and Their Transfer to the Brain. PLoS One. 2015 Nov 23;10(11):e0143640. [Content Brief]
